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KMID : 0377619960610050373
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Korean Jungang Medical Journal
1996 Volume.61 No. 5 p.373 ~ p.386
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Clinical Evaluation of Emedatine Difumarate(Remicut^(®)) on Treatment of Perennial Allergic Rhinitis
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이용배/Lee, Yong Bae
이상덕/안철민/박준우/이종혁/Lee, Sang Duck/Ahn, Cheol Min/Park, Joon Woo/Lee, Jong Hyouk
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Abstract
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A double-blind placebo-controlled study was carried out in 47 patients with perennial allergic rhinitis in order to study the effectiveness, safety and usefulness of emedastine difumarate at dose of 4mg/day, b.i.d. Patients were randomly allocated into two groups, one active ingredient(E group, 32 patients) and the other placebo(P group, 15 patients).
Most symptoms and physical findings were more improved in the ´second week compared with in the first week.
Most major symptoms such as sneezing, rhinorrhea and nasal obstruction improved significantly, but physical findings and laboratory test such as turbinate swelling, rhinorrhea amount and eosinophil count improved insignificantly, except provocation test.
Regarding the final global improvement rating, 33.3 % in the E group was observed in < moderate improvement> and more, significant differences being noted between the E and P group(p<0.05).
With respect to the global safety rating, 87.5% of the E group was assessed as
< safe>, with no significant differences between the two groups.
The global utility rate( and more) was 36.7 % for the E group, significant
differences being noted between the two groups(p<0.01).
It was suggested that Emedastine might be an effective drug for management of perennial allergic rhinitis with relatively mild side effects.
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